Airway reactivity and sphingolipids—implications for childhood asthma
نویسندگان
چکیده
منابع مشابه
Airway reactivity and sphingolipids—implications for childhood asthma
Asthma is a clinically heterogeneous disorder, whose onset and progression results from a complex interplay between genetic susceptibility, allergens, and viral triggers. Sphingolipids and altered sphingolipid metabolism have emerged as potential key contributors to the pathogenesis of asthma. Orosomucoid-like 3 gene (ORMDL3) and the asthma susceptibility locus 17q21 have been strongly and repr...
متن کاملRole of calcium in airway reactivity and asthma.
To the Editor : The recent article, "Sensitization alters contractile responses and calcium influx in human airway smooth muscle," (J ALLERGY CLIN IMMUNOL 1989 ;440-7) by Black et al .' has further contributed to the hypothesis that some alteration in the regulation of airway smooth muscle calcium may contribute another mechanism to bronchial hyperresponsiveness . The possible role of an abnorm...
متن کاملEffects of skin cooling on airway reactivity in asthma.
1. Environmental contact with cold air is a common cause of respiratory distress in obstructive lung disease, and direct and reflex changes in bronchial calibre are well documented with this stimulus when it is inhaled or contacts the exposed skin respectively. It is now known that skin chilling does not amplify the effects of breathing cold air, but it is not established if this lack of intera...
متن کاملExhaled nitric oxide correlates with airway eosinophils in childhood asthma.
BACKGROUND Exhaled nitric oxide has been proposed as a marker for airway inflammation in asthma. The aim of this study was to compare exhaled nitric oxide levels with inflammatory cells and mediators in bronchoalveolar lavage fluid from asthmatic and normal children. METHODS Children were recruited from elective surgical lists and a non-bronchoscopic bronchoalveolar lavage (BAL) was performed...
متن کاملNoninvasive Monitoring of Airway Inflammation in Childhood Asthma
Received August 31, 2006 Abstract Airway inflammation plays a central role in the pathogenesis of asthma. Accurate assessment of the degree of airway inflammation may allow us to fine-tune the anti-inflammatory treatment. There are many methods of assessing the degree of airway inflammation such as bronchial biopsy and broncho-alveolar lavage. These methods, however, are invasive and can be ver...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular and Cellular Pediatrics
سال: 2015
ISSN: 2194-7791
DOI: 10.1186/s40348-015-0025-3